Divide and rule: The role of ubiquitination in inactivation of the ERK5-MAPK cascade

Recently, we revealed that ubiquitination of MEKK2 and MEKK3 by inhibitor of apoptosis proteins (IAPs) directly disrupts MEK5/ERK5 interaction and subsequently attenuates ERK5 activation. In addition, loss of XIAP promotes human myogenic differentiation in an ERK5-dependent manner. These results rev...

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Bibliographic Details
Published in:Mol Cell Oncol
Main Authors: Schulenburg, Katharina, Glatz, Gabor, Remenyi, Attila, Rajalingam, Krishnaraj
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905217/
https://ncbi.nlm.nih.gov/pubmed/27308375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/23723548.2014.969170
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