Balance of cellular and humoral immunity determines the level of protection by HIV vaccines in rhesus macaque models of HIV infection

A guiding principle for HIV vaccine design has been that cellular and humoral immunity work together to provide the strongest degree of efficacy. However, three efficacy trials of Ad5-vectored HIV vaccines showed no protection. Transmission was increased in two of the trials, suggesting that this va...

詳細記述

保存先:
書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Fouts, Timothy R., Bagley, Kenneth, Prado, Ilia J., Bobb, Kathryn L., Schwartz, Jennifer A., Xu, Rong, Zagursky, Robert J., Egan, Michael A., Eldridge, John H., LaBranche, Celia C., Montefiori, David C., Le Buanec, Hélène, Zagury, Daniel, Pal, Ranajit, Pavlakis, George N., Felber, Barbara K., Franchini, Genoveffa, Gordon, Shari, Vaccari, Monica, Lewis, George K., DeVico, Anthony L., Gallo, Robert C.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2015
主題:
PNAS Plus
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352796/
https://ncbi.nlm.nih.gov/pubmed/25681373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423669112
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