Genomic landscape of pediatric adrenocortical tumors

Pediatric adrenocortical carcinoma is a rare malignancy with poor prognosis. Here we analyze 37 adrenocortical tumors (ACTs) by whole genome, whole exome and/or transcriptome sequencing. Most cases (91%) show loss of heterozygosity (LOH) of chromosome 11p, with uniform selection against the maternal...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Pinto, Emilia M., Chen, Xiang, Easton, John, Finkelstein, David, Liu, Zhifa, Pounds, Stanley, Rodriguez-Galindo, Carlos, Lund, Troy C., Mardis, Elaine R., Wilson, Richard K., Boggs, Kristy, Yergeau, Donald, Cheng, Jinjun, Mulder, Heather L., Manne, Jayanthi, Jenkins, Jesse, Mastellaro, Maria J., Figueiredo, Bonald C., Dyer, Michael A., Pappo, Alberto, Zhang, Jinghui, Downing, James R., Ribeiro, Raul C., Zambetti, Gerard P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352712/
https://ncbi.nlm.nih.gov/pubmed/25743702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7302
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