Germline Variants in Phosphodiesterase Genes and Genetic Predisposition to Pediatric Adrenocortical Tumors

Phosphodiesterases (PDEs) form a superfamily of enzymes that catalyze the hydrolysis of cyclic nucleotides adenosine 3′5′-cyclic monophosphate (cAMP) and guanosine 3′5′-cyclic monophosphate (cGMP) to their inactive 5′ monophosphates. cAMP plays a critical role as a second messenger in endocrine tiss...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Pinto, Emilia Modolo, Faucz, Fabio R., Paza, Luana Z., Wu, Gang, Fernandes, Elizabeth S., Bertherat, Jerome, Stratakis, Constantine A., Lalli, Enzo, Ribeiro, Raul C., Rodriguez-Galindo, Carlos, Figueiredo, Bonald C., Zambetti, Gerard P.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7072638/
https://ncbi.nlm.nih.gov/pubmed/32098292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12020506
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