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Engineering High-Potency R-spondin Adult Stem Cell Growth Factors
Secreted R-spondin proteins (RSPOs1–4) function as adult stem cell growth factors by potentiating Wnt signaling. Simultaneous binding of distinct regions of the RSPO Fu1–Fu2 domain module to the extracellular domains (ECDs) of the LGR4 G protein–coupled receptor and the ZNRF3 transmembrane E3 ubiqui...
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| Vydáno v: | Mol Pharmacol |
|---|---|
| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Pharmacology and Experimental Therapeutics
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4352588/ https://ncbi.nlm.nih.gov/pubmed/25504990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.114.095133 |
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