Cargando...

Dispersion Interactions between Urea and Nucleobases Contribute to the Destabilization of RNA by Urea in Aqueous Solution

Urea has long been used to investigate protein folding and, more recently, RNA folding. Studies have proposed that urea denatures RNA by participating in stacking interactions and hydrogen bonds with nucleic acid bases. In this study, the ability of urea to form unconventional stacking interactions...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Phys Chem B
Main Authors: Kasavajhala, Koushik, Bikkina, Swetha, Patil, Indrajit, MacKerell, Alexander D., Priyakumar, U. Deva
Formato: Artigo
Idioma:Inglês
Publicado: 2015
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352126/
https://ncbi.nlm.nih.gov/pubmed/25668757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp512414f
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!