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Dispersion Interactions between Urea and Nucleobases Contribute to the Destabilization of RNA by Urea in Aqueous Solution

Urea has long been used to investigate protein folding and, more recently, RNA folding. Studies have proposed that urea denatures RNA by participating in stacking interactions and hydrogen bonds with nucleic acid bases. In this study, the ability of urea to form unconventional stacking interactions...

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Bibliografiske detaljer
Udgivet i:J Phys Chem B
Main Authors: Kasavajhala, Koushik, Bikkina, Swetha, Patil, Indrajit, MacKerell, Alexander D., Priyakumar, U. Deva
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352126/
https://ncbi.nlm.nih.gov/pubmed/25668757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp512414f
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