XRN1 Stalling in the 5’ UTR of Hepatitis C Virus and Bovine Viral Diarrhea Virus Is Associated with Dysregulated Host mRNA Stability

We demonstrate that both Hepatitis C virus (HCV) and Bovine Viral Diarrhea virus (BVDV) contain regions in their 5’ UTRs that stall and repress the enzymatic activity of the cellular 5’-3’ exoribonuclease XRN1, resulting in dramatic changes in the stability of cellular mRNAs. We used biochemical ass...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Moon, Stephanie L., Blackinton, Jeffrey G., Anderson, John R., Dozier, Mary K., Dodd, Benjamin J. T., Keene, Jack D., Wilusz, Carol J., Bradrick, Shelton S., Wilusz, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352041/
https://ncbi.nlm.nih.gov/pubmed/25747802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004708
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