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Identification of phlebovirus and arenavirus RNA sequences that stall and repress the exoribonuclease XRN1

Regulated mRNA decay plays a vital role in determining both the level and quality of cellular gene expression. Viral RNAs must successfully evade this host RNA decay machinery to establish a productive infection. One way for RNA viruses to accomplish this is to target the cellular exoribonuclease XR...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Charley, Phillida A., Wilusz, Carol J., Wilusz, Jeffrey
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2018
Soggetti:
RNA
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766927/
https://ncbi.nlm.nih.gov/pubmed/29118186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.805796
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