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BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair
The mechanisms contributing to transcription-associated genomic instability are both complex and incompletely understood. Although R-loops are normal transcriptional intermediates, they are also associated with genomic instability. Here, we show that BRCA1 is recruited to R-loops that form normally...
Αποθηκεύτηκε σε:
Τόπος έκδοσης: | Mol Cell |
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Κύριοι συγγραφείς: | , , , , , , , , , , , , , , |
Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
Cell Press
2015
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4351672/ https://ncbi.nlm.nih.gov/pubmed/25699710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.011 |
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