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Checkpoints are blind to replication restart and recombination intermediates that result in gross chromosomal rearrangements

Replication fork inactivation can be overcome by homologous recombination, but this can cause gross chromosomal rearrangements that subsequently missegregate at mitosis, driving further chromosome instability. It is unclear when the chromosome rearrangements are generated and whether individual repl...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Mohebi, Saed, Mizuno, Ken’Ichi, Watson, Adam, Carr, Antony M., Murray, Johanne M.
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351560/
https://ncbi.nlm.nih.gov/pubmed/25721418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7357
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