Efficient and Allele-Specific Genome Editing of Disease Loci in Human iPSCs

Efficient and precise genome editing is crucial for realizing the full research and therapeutic potential of human induced pluripotent stem cells (iPSCs). Engineered nucleases including CRISPR/Cas9 and transcription activator like effector nucleases (TALENs) provide powerful tools for enhancing gene...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Smith, Cory, Abalde-Atristain, Leire, He, Chaoxia, Brodsky, Brett R, Braunstein, Evan M, Chaudhari, Pooja, Jang, Yoon-Young, Cheng, Linzhao, Ye, Zhaohui
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351458/
https://ncbi.nlm.nih.gov/pubmed/25418680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.226
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