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Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance

AIMS/HYPOTHESIS: Nicotinamide-N-methyltransferase (NNMT) was recently shown to be upregulated in mouse models of insulin resistance and obesity. So far, it is unknown whether NNMT is regulated in human disease. We have explored the hypothesis that white adipose tissue (WAT) NNMT expression and plasm...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Kannt, Aimo, Pfenninger, Anja, Teichert, Lenore, Tönjes, Anke, Dietrich, Arne, Schön, Michael R., Klöting, Nora, Blüher, Matthias
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351435/
https://ncbi.nlm.nih.gov/pubmed/25596852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-014-3490-7
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