Relationships among folate, alcohol consumption, gene variants in one-carbon metabolism and p16 (INK4a) methylation and expression in healthy breast tissues

p16 (INK4a) is a tumor suppressor gene, frequently hypermethylated in breast cancer; this epigenetic silencing of p16 (INK4a) occurs early in carcinogenesis. The risk factors and functional consequences of p16 (INK4a) methylation are unknown. Alcohol consumption, a breast cancer risk factor, impedes...

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Bibliografiske detaljer
Udgivet i:Carcinogenesis
Main Authors: Llanos, Adana A., Dumitrescu, Ramona G., Brasky, Theodore M., Liu, Zhenhua, Mason, Joel B., Marian, Catalin, Makambi, Kepher H., Spear, Scott L., Kallakury, Bhaskar V.S., Freudenheim, Jo L., Shields, Peter G.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
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Original Manuscript
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351383/
https://ncbi.nlm.nih.gov/pubmed/25344837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu219
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