Relationships among folate, alcohol consumption, gene variants in one-carbon metabolism and p16 (INK4a) methylation and expression in healthy breast tissues

p16 (INK4a) is a tumor suppressor gene, frequently hypermethylated in breast cancer; this epigenetic silencing of p16 (INK4a) occurs early in carcinogenesis. The risk factors and functional consequences of p16 (INK4a) methylation are unknown. Alcohol consumption, a breast cancer risk factor, impedes...

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Detalhes bibliográficos
Publicado no:Carcinogenesis
Main Authors: Llanos, Adana A., Dumitrescu, Ramona G., Brasky, Theodore M., Liu, Zhenhua, Mason, Joel B., Marian, Catalin, Makambi, Kepher H., Spear, Scott L., Kallakury, Bhaskar V.S., Freudenheim, Jo L., Shields, Peter G.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Original Manuscript
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351383/
https://ncbi.nlm.nih.gov/pubmed/25344837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgu219
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