Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation

Ribonucleotides are frequently incorporated into DNA during eukaryotic replication. Here we map the genome-wide distribution of these ribonucleotides as markers of replication enzymology in budding yeast, using a new 5′-DNA end-mapping method, Hydrolytic End Sequencing. HydEn-Seq of DNA from ribonuc...

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Udgivet i:Nat Struct Mol Biol
Main Authors: Clausen, Anders R., Lujan, Scott A., Burkholder, Adam B., Orebaugh, Clinton D., Williams, Jessica S., Clausen, Maryam F., Malc, Ewa P., Mieczkowski, Piotr A., Fargo, David C., Smith, Duncan J., Kunkel, Thomas A.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351163/
https://ncbi.nlm.nih.gov/pubmed/25622295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2957
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