Peptide/MHC tetramer-based sorting of CD8(+) T cells to a leukemia antigen yields clonotypes drawn nonspecifically from an underlying restricted repertoire

Testing of T cell-based cancer therapeutics often involves measuring cancer antigen-specific T-cell populations with the assumption that they arise from in vivo clonal expansion. This analysis, using peptide/MHC tetramers, is often ambiguous. From a leukemia cell line, we identified a CDK4-derived p...

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Foilsithe in:Cancer Immunol Res
Main Authors: Hunsucker, Sally A., McGary, Colleen S., Vincent, Benjamin G., Enyenihi, Atim A., Waugh, Jennifer P., McKinnon, Karen P., Bixby, Lisa M., Ropp, Patricia A., Coghill, James M., Wood, William A., Gabriel, Don A., Sarantopoulos, Stefanie, Shea, Thomas C., Serody, Jonathan S., Alatrash, Gheath, Rodriguez-Cruz, Tania, Lizée, Gregory, Buntzman, Adam S., Frelinger, Jeffrey A., Glish, Gary L., Armistead, Paul M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351150/
https://ncbi.nlm.nih.gov/pubmed/25576336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0001
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