Peptide/MHC tetramer-based sorting of CD8(+) T cells to a leukemia antigen yields clonotypes drawn nonspecifically from an underlying restricted repertoire

Testing of T cell-based cancer therapeutics often involves measuring cancer antigen-specific T-cell populations with the assumption that they arise from in vivo clonal expansion. This analysis, using peptide/MHC tetramers, is often ambiguous. From a leukemia cell line, we identified a CDK4-derived p...

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Publicado no:Cancer Immunol Res
Main Authors: Hunsucker, Sally A., McGary, Colleen S., Vincent, Benjamin G., Enyenihi, Atim A., Waugh, Jennifer P., McKinnon, Karen P., Bixby, Lisa M., Ropp, Patricia A., Coghill, James M., Wood, William A., Gabriel, Don A., Sarantopoulos, Stefanie, Shea, Thomas C., Serody, Jonathan S., Alatrash, Gheath, Rodriguez-Cruz, Tania, Lizée, Gregory, Buntzman, Adam S., Frelinger, Jeffrey A., Glish, Gary L., Armistead, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351150/
https://ncbi.nlm.nih.gov/pubmed/25576336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-14-0001
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