Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum

Epigenetic mechanisms regulate programmed gene expression during prenatal neurogenesis and serve as a mediator between genetics and environment in postnatal life. The recent discovery of 5-hydroxymethylcytosine (5-hmC), with highest concentration in the brain, has added a new dimension to epigenetic...

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Publicado en:Transl Psychiatry
Autores principales: James, S J, Shpyleva, S, Melnyk, S, Pavliv, O, Pogribny, I P
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350522/
https://ncbi.nlm.nih.gov/pubmed/25290267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tp.2014.87
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