Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich’s Ataxia

Eitemau Tebyg

• Rationale for the Development of 2-Aminobenzamide Histone Deacetylase Inhibitors as Therapeutics for Friedreich Ataxia
  gan: Soragni, Elisabetta, et al.
  Cyhoeddwyd: (2012)
• Translating HDAC inhibitors in Friedrich's ataxia
  gan: Soragni, Elisabetta, et al.
  Cyhoeddwyd: (2016)
• Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model
  gan: Sandi, Chiranjeevi, et al.
  Cyhoeddwyd: (2011)
• Two New Pimelic Diphenylamide HDAC Inhibitors Induce Sustained Frataxin Upregulation in Cells from Friedreich's Ataxia Patients and in a Mouse Model
  gan: Rai, Myriam, et al.
  Cyhoeddwyd: (2010)
• Chemical probes identify a role for histone deacetylase 3 in Friedreich’s ataxia gene silencing
  gan: Xu, Chunping, et al.
  Cyhoeddwyd: (2009)