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Mechanism of Action of 2-Aminobenzamide HDAC Inhibitors in Reversing Gene Silencing in Friedreich’s Ataxia

The genetic defect in Friedreich’s ataxia (FRDA) is the hyperexpansion of a GAA•TTC triplet in the first intron of the FXN gene, encoding the essential mitochondrial protein frataxin. Histone post-translational modifications near the expanded repeats are consistent with heterochromatin formation and...

詳細記述

保存先:
書誌詳細
出版年:Front Neurol
主要な著者: Soragni, Elisabetta, Chou, C. James, Rusche, James R., Gottesfeld, Joel M.
フォーマット: Artigo
言語:Inglês
出版事項: Frontiers Media S.A. 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350406/
https://ncbi.nlm.nih.gov/pubmed/25798128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fneur.2015.00044
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