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Chemical probes identify a role for histone deacetylase 3 in Friedreich’s ataxia gene silencing
We recently identified a novel class of pimelic diphenylamide histone deacetylase (HDAC) inhibitors that show promise as therapeutics in the neurodegenerative diseases Friedreich’s ataxia (FRDA) and Huntington’s disease. Here we describe chemical approaches to identify the HDAC enzyme target of thes...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2909763/ https://ncbi.nlm.nih.gov/pubmed/19778726 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.07.010 |
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