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Chemical probes identify a role for histone deacetylase 3 in Friedreich’s ataxia gene silencing

We recently identified a novel class of pimelic diphenylamide histone deacetylase (HDAC) inhibitors that show promise as therapeutics in the neurodegenerative diseases Friedreich’s ataxia (FRDA) and Huntington’s disease. Here we describe chemical approaches to identify the HDAC enzyme target of thes...

詳細記述

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書誌詳細
主要な著者: Xu, Chunping, Soragni, Elisabetta, Chou, C. James, Herman, David, Plasterer, Heather L., Rusche, James R., Gottesfeld, Joel M.
フォーマット: Artigo
言語:Inglês
出版事項: 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909763/
https://ncbi.nlm.nih.gov/pubmed/19778726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.07.010
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