Llwytho...

Chemical probes identify a role for histone deacetylase 3 in Friedreich’s ataxia gene silencing

We recently identified a novel class of pimelic diphenylamide histone deacetylase (HDAC) inhibitors that show promise as therapeutics in the neurodegenerative diseases Friedreich’s ataxia (FRDA) and Huntington’s disease. Here we describe chemical approaches to identify the HDAC enzyme target of thes...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xu, Chunping, Soragni, Elisabetta, Chou, C. James, Herman, David, Plasterer, Heather L., Rusche, James R., Gottesfeld, Joel M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909763/
https://ncbi.nlm.nih.gov/pubmed/19778726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.07.010
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