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Chemical probes identify a role for histone deacetylase 3 in Friedreich’s ataxia gene silencing

We recently identified a novel class of pimelic diphenylamide histone deacetylase (HDAC) inhibitors that show promise as therapeutics in the neurodegenerative diseases Friedreich’s ataxia (FRDA) and Huntington’s disease. Here we describe chemical approaches to identify the HDAC enzyme target of thes...

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Bibliografische gegevens
Hoofdauteurs: Xu, Chunping, Soragni, Elisabetta, Chou, C. James, Herman, David, Plasterer, Heather L., Rusche, James R., Gottesfeld, Joel M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2909763/
https://ncbi.nlm.nih.gov/pubmed/19778726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.07.010
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