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Translating HDAC inhibitors in Friedrich's ataxia
INTRODUCTION: Friedreich's ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by expansion of a GAA·TTC triplet in the first intron of the FXN gene, encoding the essential mitochondrial protein frataxin. Repeat expansion results in transcriptional silencing through an epig...
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| Publicado no: | Expert Opin Orphan Drugs |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5380149/ https://ncbi.nlm.nih.gov/pubmed/28392990 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21678707.2016.1215910 |
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