Mechanism of Action of Thalassospiramides, A New Class of Calpain Inhibitors

Thalassospiramides comprise a large family of lipopeptide natural products produced by Thalassospira and Tistrella marine bacteria. Here we provide further evidence of their nanomolar inhibitory activity against the human calpain 1 protease. Analysis of structure-activity relationship data supported...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Lu, Liang, Meehan, Michael J., Gu, Shuo, Chen, Zhilong, Zhang, Weipeng, Zhang, Gen, Liu, Lingli, Huang, Xuhui, Dorrestein, Pieter C., Xu, Ying, Moore, Bradley S., Qian, Pei-Yuan
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4350077/
https://ncbi.nlm.nih.gov/pubmed/25740631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08783
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