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Mechanism of Action of Thalassospiramides, A New Class of Calpain Inhibitors
Thalassospiramides comprise a large family of lipopeptide natural products produced by Thalassospira and Tistrella marine bacteria. Here we provide further evidence of their nanomolar inhibitory activity against the human calpain 1 protease. Analysis of structure-activity relationship data supported...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4350077/ https://ncbi.nlm.nih.gov/pubmed/25740631 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08783 |
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