The Neddylation-Cullin 2-RBX1 E3 Ligase Axis Targets Tumor Suppressor RhoB for Degradation in Liver Cancer

The neddylation-cullin-RING E3 ligase (CRL) pathway has recently been identified as a potential oncogenic event and attractive anticancer target; however, its underlying mechanisms have not been well elucidated. In this study, RhoB, a well known tumor suppressor, was identified and validated with an...

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Dettagli Bibliografici
Pubblicato in:Mol Cell Proteomics
Autori principali: Xu, Junfeng, Li, Lihui, Yu, Guangyang, Ying, Wantao, Gao, Qiang, Zhang, Wenjuan, Li, Xianyu, Ding, Chen, Jiang, Yanan, Wei, Dongping, Duan, Shengzhong, Lei, Qunying, Li, Peng, Shi, Tieliu, Qian, Xiaohong, Qin, Jun, Jia, Lijun
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Biochemistry and Molecular Biology 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349972/
https://ncbi.nlm.nih.gov/pubmed/25540389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M114.045211
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