Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways

AIM: To investigate the effects of piperlongumine (PL), an anticancer alkaloid from long pepper plants, on the primary myeloid leukemia cells from patients and the mechanisms of action. METHODS: Human BM samples were obtained from 9 patients with acute or chronic myeloid leukemias and 2 patients wit...

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Bibliographic Details
Published in:Acta Pharmacol Sin
Main Authors: Xiong, Xin-xin, Liu, Ju-mei, Qiu, Xin-yao, Pan, Feng, Yu, Shang-bin, Chen, Xiao-qian
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349924/
https://ncbi.nlm.nih.gov/pubmed/25619389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2014.141
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