Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis

INTRODUCTION: Smoking is a well-established risk factor for rheumatoid arthritis (RA), and it has been proposed that smoking-induced citrullination renders autoantigens immunogenic. To investigate this mechanism, we examined human lung tissue from 40 subjects with defined smoking status, with or wit...

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Detalhes bibliográficos
Publicado no:Arthritis Res Ther
Main Authors: Lugli, Elena B, Correia, Raquel ESM, Fischer, Roman, Lundberg, Karin, Bracke, Ken R, Montgomery, Anna B, Kessler, Benedikt M, Brusselle, Guy G, Venables, Patrick J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349479/
https://ncbi.nlm.nih.gov/pubmed/25600626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-015-0520-x
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