A Surprising Role for the Sch9 Protein Kinase in Chromosome Segregation in Candida albicans

The AGC kinase Sch9 regulates filamentation in Candida albicans. Here, we show that Sch9 binding is most enriched at the centromeres in C. albicans, but not in Saccharomyces cerevisiae. Deletion of CaSch9 leads to a 150- to 750-fold increase in chromosome loss. Thus, we report a previously unknown r...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Genetics
Egile Nagusiak: Varshney, Neha, Schaekel, Alida, Singha, Rima, Chakraborty, Tanmoy, van Wijlick, Lasse, Ernst, Joachim F., Sanyal, Kaustuv
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Genetics Society of America 2015
Gaiak:
Communications
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349062/
https://ncbi.nlm.nih.gov/pubmed/25591453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.173542
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