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A Surprising Role for the Sch9 Protein Kinase in Chromosome Segregation in Candida albicans
The AGC kinase Sch9 regulates filamentation in Candida albicans. Here, we show that Sch9 binding is most enriched at the centromeres in C. albicans, but not in Saccharomyces cerevisiae. Deletion of CaSch9 leads to a 150- to 750-fold increase in chromosome loss. Thus, we report a previously unknown r...
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| Udgivet i: | Genetics |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Genetics Society of America
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4349062/ https://ncbi.nlm.nih.gov/pubmed/25591453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.173542 |
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