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Targeting miR-23a in CD8(+) cytotoxic T lymphocytes prevents tumor-dependent immunosuppression
CD8(+) cytotoxic T lymphocytes (CTLs) have potent antitumor activity and therefore are leading candidates for use in tumor immunotherapy. The application of CTLs for clinical use has been limited by the susceptibility of ex vivo–expanded CTLs to become dysfunctional in response to immunosuppressive...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4348954/ https://ncbi.nlm.nih.gov/pubmed/25347474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76561 |
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