Targeting miR-23a in CD8(+) cytotoxic T lymphocytes prevents tumor-dependent immunosuppression

CD8(+) cytotoxic T lymphocytes (CTLs) have potent antitumor activity and therefore are leading candidates for use in tumor immunotherapy. The application of CTLs for clinical use has been limited by the susceptibility of ex vivo–expanded CTLs to become dysfunctional in response to immunosuppressive...

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Dades bibliogràfiques
Publicat a:J Clin Invest
Autors principals: Lin, Regina, Chen, Ling, Chen, Gang, Hu, Chunyan, Jiang, Shan, Sevilla, Jose, Wan, Ying, Sampson, John H., Zhu, Bo, Li, Qi-Jing
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348954/
https://ncbi.nlm.nih.gov/pubmed/25347474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76561
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