The tumor microenvironment disarms CD8(+) T lymphocyte function via a miR-26a-EZH2 axis

One of the most important factors that limit the potency of CD8(+) cytotoxic T lymphocyte (CTL) responses is the tumor microenvironment (TME). Here, we provide evidence that miR-26a is a negative regulator of CTL function in the TME. Specifically, we identified miR-26a as a crucial suppressor gene i...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Long, Haixia, Xiang, Tong, Luo, Jing, Li, Fei, Lin, Regina, Liu, Siqi, Jiang, Shan, Hu, Chunyan, Chen, Gang, Wong, Elizabeth, Wan, Ying, Li, Qi-Jing, Zhu, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214597/
https://ncbi.nlm.nih.gov/pubmed/28123882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2016.1245267
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