Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis

Chromosomal translocation that results in fusion of the genes encoding RNA-binding protein EWS and transcription factor FLI1 (EWS-FLI1) is pathognomonic for Ewing sarcoma. EWS-FLI1 alters gene expression through mechanisms that are not completely understood. We performed RNA sequencing (RNAseq) anal...

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Bibliografiska uppgifter
I publikationen:J Clin Invest
Huvudupphovsmän: Marques Howarth, Michelle, Simpson, David, Ngok, Siu P., Nieves, Bethsaida, Chen, Ron, Siprashvili, Zurab, Vaka, Dedeepya, Breese, Marcus R., Crompton, Brian D., Alexe, Gabriela, Hawkins, Doug S., Jacobson, Damon, Brunner, Alayne L., West, Robert, Mora, Jaume, Stegmaier, Kimberly, Khavari, Paul, Sweet-Cordero, E. Alejandro
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348951/
https://ncbi.nlm.nih.gov/pubmed/25401475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72124
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