Phase II Study of Everolimus and Letrozole in Patients With Recurrent Endometrial Carcinoma

PURPOSE: The phosphoinositol-3 kinase (PI3K) pathway is frequently dysregulated in endometrial cancer (EC). Hormonal manipulation leads to response in some patients with EC, but resistance derived from PI3K pathway activation has been documented. Targeting mammalian target of rapamycin (mTOR) may ov...

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Bibliographische Detailangaben
Veröffentlicht in:J Clin Oncol
Hauptverfasser: Slomovitz, Brian M., Jiang, Yunyun, Yates, Melinda S., Soliman, Pamela T., Johnston, Taren, Nowakowski, Maureen, Levenback, Charles, Zhang, Qian, Ring, Kari, Munsell, Mark F., Gershenson, David M., Lu, Karen H., Coleman, Robert L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Clinical Oncology 2015
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ORIGINAL REPORTS
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348638/
https://ncbi.nlm.nih.gov/pubmed/25624430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2014.58.3401
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