A novel GAA-repeat-expansion-based mouse model of Friedreich’s ataxia

Friedreich’s ataxia (FRDA) is an autosomal recessive neurodegenerative disorder caused by a GAA repeat expansion mutation within intron 1 of the FXN gene, resulting in reduced levels of frataxin protein. We have previously reported the generation of human FXN yeast artificial chromosome (YAC) transg...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Anjomani Virmouni, Sara, Ezzatizadeh, Vahid, Sandi, Chiranjeevi, Sandi, Madhavi, Al-Mahdawi, Sahar, Chutake, Yogesh, Pook, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Limited 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348561/
https://ncbi.nlm.nih.gov/pubmed/25681319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.018952
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