PHD Domain-Mediated E3 Ligase Activity Directs Intramolecular Sumoylation of an Adjacent Bromodomain which is Required for Gene Silencing

Tandem PHD and bromodomains are often found in chromatin-associated proteins and have been shown to cooperate in gene silencing. Each domain can bind specifically modified histones: the mechanisms of cooperation between these domains are unknown. We show that the PHD domain of the KAP1 corepressor f...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Ivanov, Alexey V., Peng, Hongzhuang, Yurchenko, Vyacheslav, Yap, Kyoko L., Negorev, Dmitri G., Schultz, David C., Psulkowski, Elyse, Fredericks, William J., White, David E., Maul, Gerd G., Sadofsky, Moshe J., Zhou, Ming-Ming, Rauscher, Frank J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348069/
https://ncbi.nlm.nih.gov/pubmed/18082607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.11.012
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