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The RAG1 N-terminal domain is an E3 ubiquitin ligase
RAG1 and RAG2 initiate V(D)J recombination, which is the assembly of immunoglobulin and T cell receptor genes. The N-terminal region of RAG1 can be deleted, leaving an enzymatic “core” able to catalyze the complete reaction. Here we report that the N-terminal portion of RAG1 has a distinct enzymatic...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC196008/ https://ncbi.nlm.nih.gov/pubmed/12629039 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1058103 |
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