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The RAG1 N-terminal domain is an E3 ubiquitin ligase

RAG1 and RAG2 initiate V(D)J recombination, which is the assembly of immunoglobulin and T cell receptor genes. The N-terminal region of RAG1 can be deleted, leaving an enzymatic “core” able to catalyze the complete reaction. Here we report that the N-terminal portion of RAG1 has a distinct enzymatic...

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Detalhes bibliográficos
Main Authors: Yurchenko, Vyacheslav, Xue, Zhu, Sadofsky, Moshe
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196008/
https://ncbi.nlm.nih.gov/pubmed/12629039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1058103
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