PHD Domain-Mediated E3 Ligase Activity Directs Intramolecular Sumoylation of an Adjacent Bromodomain which is Required for Gene Silencing

Tandem PHD and bromodomains are often found in chromatin-associated proteins and have been shown to cooperate in gene silencing. Each domain can bind specifically modified histones: the mechanisms of cooperation between these domains are unknown. We show that the PHD domain of the KAP1 corepressor f...

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Vydáno v:Mol Cell
Hlavní autoři: Ivanov, Alexey V., Peng, Hongzhuang, Yurchenko, Vyacheslav, Yap, Kyoko L., Negorev, Dmitri G., Schultz, David C., Psulkowski, Elyse, Fredericks, William J., White, David E., Maul, Gerd G., Sadofsky, Moshe J., Zhou, Ming-Ming, Rauscher, Frank J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348069/
https://ncbi.nlm.nih.gov/pubmed/18082607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.11.012
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