Pharmacokinetic-pharmacodynamic analysis to evaluate the effect of moxifloxacin on QT interval prolongation in healthy Korean male subjects

A single 400 mg dose of moxifloxacin has been the standard positive control for thorough QT (TQT) studies. However, it is not clearly known whether a 400 mg dose is also applicable to TQT studies in Asian subjects, including Koreans. Thus, we aimed to develop a pharmacokinetic (PK)-pharmacodynamic (...

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Detalles Bibliográficos
Publicado en:Drug Des Devel Ther
Main Authors: Hong, Taegon, Han, Seunghoon, Lee, Jongtae, Jeon, Sangil, Park, Gab-Jin, Park, Wan-Su, Lim, Kyoung Soo, Chung, Jae-Yong, Yu, Kyung-Sang, Yim, Dong-Seok
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2015
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348051/
https://ncbi.nlm.nih.gov/pubmed/25750520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S79772
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