The Chromatin-Modifying Enzyme Ezh2 Is Critical for the Maintenance of Regulatory T Cell Identity after Activation

Regulatory T cells (Treg cells) are required for immune homeostasis. Chromatin remodeling is essential for establishing diverse cellular identities, but how the epigenetic program in Treg cells is maintained throughout the dynamic activation process remains unclear. Here we have shown that CD28 co-s...

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Veröffentlicht in:Immunity
Hauptverfasser: DuPage, Michel, Chopra, Gaurav, Quiros, Jason, Rosenthal, Wendy L., Morar, Malika M., Holohan, Dan, Zhang, Ruan, Turka, Laurence, Marson, Alexander, Bluestone, Jeffrey A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347854/
https://ncbi.nlm.nih.gov/pubmed/25680271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.01.007
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