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Stemness factor Sall4 is required for DNA damage response in embryonic stem cells

Mouse embryonic stem cells (ESCs) are genetically more stable than somatic cells, thereby preventing the passage of genomic abnormalities to their derivatives including germ cells. The underlying mechanisms, however, remain largely unclear. In this paper, we show that the stemness factor Sall4 is re...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Xiong, Jianhua, Todorova, Dilyana, Su, Ning-Yuan, Kim, Jinchul, Lee, Pei-Jen, Shen, Zhouxin, Briggs, Steven P., Xu, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347641/
https://ncbi.nlm.nih.gov/pubmed/25733712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201408106
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