Cytokine therapy reverses NK cell anergy in MHC-deficient tumors

Various cytokines have been evaluated as potential anticancer drugs; however, most cytokine trials have shown relatively low efficacy. Here, we found that treatments with IL-12 and IL-18 or with a mutant form of IL-2 (the “superkine” called H9) provided substantial therapeutic benefit for mice speci...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Ardolino, Michele, Azimi, Camillia S., Iannello, Alexandre, Trevino, Troy N., Horan, Lucas, Zhang, Lily, Deng, Weiwen, Ring, Aaron M., Fischer, Suzanne, Garcia, K. Christopher, Raulet, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347250/
https://ncbi.nlm.nih.gov/pubmed/25329698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74337
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