IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction

The intracellular scaffold protein IQGAP1 supports protein complexes in conjunction with numerous binding partners involved in multiple cellular processes. Here, we determined that IQGAP1 modulates airway smooth muscle contractility. Compared with WT controls, at baseline as well as after immune sen...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Bhattacharya, Mallar, Sundaram, Aparna, Kudo, Makoto, Farmer, Jessica, Ganesan, Previn, Khalifeh-Soltani, Amin, Arjomandi, Mehrdad, Atabai, Kamran, Huang, Xiaozhu, Sheppard, Dean
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2014
Soggetti:
Brief Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347230/
https://ncbi.nlm.nih.gov/pubmed/25271629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76658
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