IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction

The intracellular scaffold protein IQGAP1 supports protein complexes in conjunction with numerous binding partners involved in multiple cellular processes. Here, we determined that IQGAP1 modulates airway smooth muscle contractility. Compared with WT controls, at baseline as well as after immune sen...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Bhattacharya, Mallar, Sundaram, Aparna, Kudo, Makoto, Farmer, Jessica, Ganesan, Previn, Khalifeh-Soltani, Amin, Arjomandi, Mehrdad, Atabai, Kamran, Huang, Xiaozhu, Sheppard, Dean
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2014
Schlagworte:
Brief Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347230/
https://ncbi.nlm.nih.gov/pubmed/25271629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76658
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