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Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome
Excessive activation of the NLRP3 inflammasome results in damaging inflammation, yet the regulators of this process remain poorly defined. Herein, we show that the orphan nuclear receptor small heterodimer partner (SHP) is a negative regulator of NLRP3 inflammasome activation. NLRP3 inflammasome act...
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| 出版年: | Nat Commun |
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| 主要な著者: | , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Pub. Group
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4347017/ https://ncbi.nlm.nih.gov/pubmed/25655831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7115 |
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