Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome

Excessive activation of the NLRP3 inflammasome results in damaging inflammation, yet the regulators of this process remain poorly defined. Herein, we show that the orphan nuclear receptor small heterodimer partner (SHP) is a negative regulator of NLRP3 inflammasome activation. NLRP3 inflammasome act...

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Pubblicato in:Nat Commun
Autori principali: Yang, Chul-Su, Kim, Jwa-Jin, Kim, Tae Sung, Lee, Phil Young, Kim, Soo Yeon, Lee, Hye-Mi, Shin, Dong-Min, Nguyen, Loi T., Lee, Moo-Seung, Jin, Hyo Sun, Kim, Kwang-Kyu, Lee, Chul-Ho, Kim, Myung Hee, Park, Sung Goo, Kim, Jin-Man, Choi, Hueng-Sik, Jo, Eun-Kyeong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347017/
https://ncbi.nlm.nih.gov/pubmed/25655831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7115
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