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Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome
Excessive activation of the NLRP3 inflammasome results in damaging inflammation, yet the regulators of this process remain poorly defined. Herein, we show that the orphan nuclear receptor small heterodimer partner (SHP) is a negative regulator of NLRP3 inflammasome activation. NLRP3 inflammasome act...
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| Pubblicato in: | Nat Commun |
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| Autori principali: | , , , , , , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Pub. Group
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4347017/ https://ncbi.nlm.nih.gov/pubmed/25655831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7115 |
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