Small Heterodimer Partner-Targeting Therapy Inhibits Systemic Inflammatory Responses through Mitochondrial Uncoupling Protein 2

The orphan nuclear receptor, small heterodimer partner (SHP), appears to play a negative regulatory role in innate immune signaling. Emerging evidence warrants further study on the therapeutic targeting of SHP to suppress excessive and deleterious inflammation. Here we show that fenofibrate, which t...

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Detalhes bibliográficos
Main Authors: Yang, Chul-Su, Yuk, Jae-Min, Kim, Jwa-Jin, Hwang, Jung Hwan, Lee, Chul-Ho, Kim, Jin-Man, Oh, Goo Taeg, Choi, Hueng-Sik, Jo, Eun-Kyeong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660347/
https://ncbi.nlm.nih.gov/pubmed/23704907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063435
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