Small Heterodimer Partner-Targeting Therapy Inhibits Systemic Inflammatory Responses through Mitochondrial Uncoupling Protein 2

The orphan nuclear receptor, small heterodimer partner (SHP), appears to play a negative regulatory role in innate immune signaling. Emerging evidence warrants further study on the therapeutic targeting of SHP to suppress excessive and deleterious inflammation. Here we show that fenofibrate, which t...

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Bibliographic Details
Main Authors: Yang, Chul-Su, Yuk, Jae-Min, Kim, Jwa-Jin, Hwang, Jung Hwan, Lee, Chul-Ho, Kim, Jin-Man, Oh, Goo Taeg, Choi, Hueng-Sik, Jo, Eun-Kyeong
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3660347/
https://ncbi.nlm.nih.gov/pubmed/23704907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063435
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