Loss of hepatocyte EGFR has no effect alone but exacerbates carbon tetrachloride-induced liver injury and impairs regeneration in hepatocyte Met-deficient mice

The role(s) of the epidermal growth factor receptor (EGFR) in hepatocytes is unknown. We generated a murine hepatocyte specific-EGFR knockout (KO) model to evaluate how loss of hepatocellular EGFR expression affects processes such as EGF clearance, circulating EGF concentrations, and liver regenerat...

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Vydáno v:Am J Physiol Gastrointest Liver Physiol
Hlavní autoři: Scheving, Lawrence A., Zhang, Xiuqi, Stevenson, Mary C., Threadgill, David W., Russell, William E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2014
Témata:
Liver and Biliary Tract
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346751/
https://ncbi.nlm.nih.gov/pubmed/25414100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00364.2014
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