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Tim-1 is essential for induction and maintenance of IL-10 in regulatory B cells and their regulation of tissue inflammation
T cell Ig and mucin domain (Tim)-1 identifies IL-10-producing regulatory B cells (Bregs). Mice on the C57BL/6 background harboring a loss of function Tim-1 mutant showed progressive loss of IL-10 production in B cells and with age developed severe multi-organ tissue inflammation. We demonstrate that...
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| Udgivet i: | J Immunol |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4346345/ https://ncbi.nlm.nih.gov/pubmed/25582854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402632 |
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