Endothelial p53 Deletion Improves Angiogenesis and Prevents Cardiac Fibrosis and Heart Failure Induced by Pressure Overload in Mice

BACKGROUND: Cardiac dysfunction developing in response to chronic pressure overload is associated with apoptotic cell death and myocardial vessel rarefaction. We examined whether deletion of tumor suppressor p53 in endothelial cells may prevent the transition from cardiac hypertrophy to heart failur...

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Dettagli Bibliografici
Pubblicato in:J Am Heart Assoc
Autori principali: Gogiraju, Rajinikanth, Xu, Xingbo, Bochenek, Magdalena L., Steinbrecher, Julia H., Lehnart, Stephan E., Wenzel, Philip, Kessel, Michael, Zeisberg, Elisabeth M., Dobbelstein, Matthias, Schäfer, Katrin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2015
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4345879/
https://ncbi.nlm.nih.gov/pubmed/25713289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.001770
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